Publications by authors named "B J Gleizes"

Polymorphonuclear (PMN) functions were assessed in 55 patients with asthma or bronchial bacterial infection to evaluate the systemic phagocyte capability of patients with bronchopulmonary diseases. Random migration, nitroblue tetrazolium dye reduction, and Candida killing activity were markedly decreased in the 2 types of patients studied. PMN dysfunction was more pronounced in the most affected and heavily treated patients.

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Human polynuclear neutrophilic function was studied to determine the role of alcohol in the increased susceptibility to infection of chronic alcoholics: in vitro studies investigated the effects of different concentrations of ethanol; in vivo studies included comparison with healthy subjects after alcohol intake, with excessive drinkers without liver disease and with chronic alcoholics with confirmed cirrhosis. In vitro depression of polynuclear neutrophilic function was observed only with significantly higher concentrations of ethanol than encountered clinically. In social and excessive drinkers, phagocytosis was decreased but there was no change in bactericidal activity.

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The slime of Pseudomonas aeruginosa markedly impaired the in vitro motility, endocytosis, and phagosome formation of normal human polymorphonuclear neutrophils. This profound impairment of neutrophils, although without alteration of their viability, may contribute to the virulence of this microorganism.

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The in vitro effect of a ribosomal extract of Klebsiella pneumoniae on polymorphonuclear leukocytes (PMNs) from 22 healthy subjects was assessed. With the concentrations used (2, 4 and 6 micrograms/10(6) cells), no significant modification of the superoxide anion production was observed. While random migration was only slightly reduced, the chemotactic response of PMNs toward zymosan activated serum was significantly decreased with the three concentrations of the ribosomal extract.

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Polymorphonuclear (PMN) functions were assessed in 93 non-selected hospitalized patients, 32 active, healthy, elderly controls and 29 young controls. The results confirm the impairment of PMN functions in the aged. However, PMN functions in hospitalized older persons are similar to those in non-institutionalized controls, and underlying diseases and treatment do not seem to aggravate the PMN impairment.

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