Effects of tranexamic acid on human nasal ciliary beat frequency.

Background: Patients with recurrent epistaxis, particularly due to hereditary hemorrhagic telangiectasia (HHT) are recommended to apply topical tranexamic acid (TXA) to reduce bleeding events. Those patients may suffer ciliary dysfunction due to TXA's effects on ciliary beating frequency (CBF) and their consequences.

Methodology/principal: Human nasal epithelial cells were harvested with a nasal brush in 30 healthy subjects.

Transoral laser microsurgery for glottic cancer in the elderly: Efficacy and safety.

Background: Data about the results of transoral laser microsurgery (TLM) in elderly patients are limited.

Methods: A retrospective study of 72 consecutive cases of glottic carcinoma (63 pT1 and 9 pT2 cases) in elderly patients (≥70 years old, mean 76 years) treated with TLM was made. A systematic review of the literature was performed.