Publications by authors named "B J D'Souza"

Amidst the COVID-19 pandemic, telehealth (TH) has gained increasing relevance in colorectal patient care, prompting an audit of the TH clinic at a tertiary colorectal unit. This study evaluated telephone-based consultations' clinical efficacy and diagnostic thresholds for new lower gastrointestinal (LGI) bleeding referrals. We conducted a quality assurance audit of the per rectal (PR) bleeding TH clinic at Northern Hospital Victoria, evaluating new LGI bleeding referrals.

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Background And Aims: Crohn's perianal fistula healing rates remain low. We evaluated the efficacy of a protocolized multidisciplinary treatment strategy optimizing care in adults with Crohn's perianal fistulas.

Methods: A new treatment strategy was established at a single tertiary center.

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Fibrotic-like abnormalities are present in 60% of a single-center, longitudinal, multi-ethnic cohort 3-years after severe COVID-19. They are independently associated with male sex, low BMI, shorter telomere length, increased severity of illness, and mechanical ventilation; Black race and asthma are protective. Participants with fibrotic-like abnormalities are more likely to have reduced diffusion capacity and 6-minute walk distance.

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  • MRSA infections pose a significant public health challenge, prompting the need for new treatment strategies beyond conventional antibiotics.
  • The study explored the effects of TRP ion channel inhibitors on MRSA skin infections in mice, finding that blocking TRPA1 reduced infection severity, while TRPV1 deletion had no significant impact.
  • The research revealed that inhibiting TRPA1 influenced protein expressions and metabolic pathways related to inflammation and immune response, suggesting TRPA1 antagonism could be an effective, low-cost treatment option for MRSA.
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  • The study investigates the long-term risk of damage to the right coronary artery (RCA) after patients undergo radiofrequency ablation (RFA) for atrial flutter related to the cavotricuspid isthmus (CTI).
  • A comparison was made between patients who had CTI RFA and those who only received ablation for atrial fibrillation (AF), with coronary angiography performed afterward to evaluate any differences in RCA stenosis.
  • Results indicate that there were no significant differences in the incidence or severity of RCA stenoses between the two groups, suggesting that CTI RFA does not increase the risk of RCA damage in the long term.
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