Publications by authors named "B J C van den Bosch"
Following transcript release during intrinsic termination, Escherichia coli RNA polymerase (RNAP) often remains associated with DNA in a post-termination complex (PTC). RNAPs in PTCs are removed from the DNA by the SWI2/SNF2 adenosine triphosphatase (ATPase) RapA. Here we determined PTC structures on negatively supercoiled DNA and with RapA engaged to dislodge the PTC.
View Article and Find Full Text PDFAmong the different layers of the cornea, the corneal endothelium, which is composed of corneal endothelial cells (CEC), plays a key role in the maintenance of cornea transparency. Based on the donor shortages and the limitations associated with transplantation, in this work we have developed collagen hydrogels with different patterned structures on the surface to provide topographies in ranges similar to the natural environment that CEC sense. This aimed at stimulating cells to maintain a typical CEC phenotype and provide alternatives to corneal transplantation.
View Article and Find Full Text PDFArticle Synopsis
- * Methods: Over 48 weeks, 101 Black women (median age 35) were transitioned to the new regimen, and the study assessed retention rates, viral suppression, weight changes, and lipid panel improvements.
- * Results: Retention was high (92%), with over 90% maintaining viral suppression. Participants experienced an average weight gain of 2.7 kg and significant improvements in cholesterol and triglyceride
Article Synopsis
- Neuroimaging and fluid biomarkers, like MRI and cerebrospinal fluid (CSF) analysis, help distinguish frontotemporal dementia (FTD) from Alzheimer's disease (AD).
- A machine learning algorithm was developed to calculate individual probabilistic scores, yielding an 82% accuracy rate for differentiating between AD and FTD using MRI alone.
- Combining MRI data with CSF biomarkers improved diagnostic accuracy and confidence, making the algorithm a promising tool for clinical use, especially in scenarios with limited access to expert diagnoses.
Article Synopsis
- Porcine deltacoronavirus (PDCoV) poses a significant threat to piglets, causing severe diarrhea and high mortality, and raises public health concerns due to possible human infections.
- A genome-wide CRISPR/Cas9 library screening identified important host genes involved in PDCoV infection, notably ANPEP (the receptor for PDCoV) and C16orf62, which plays a role in viral entry by influencing receptor expression.
- The study is the first of its kind focusing on PDCoV, highlighting the potential of targeting host factors like C16orf62 for developing antiviral treatments.