Publications by authors named "B J Bolwell"
Therapy-related myeloid neoplasms (tMN) are complications of cytotoxic therapies. Risk of tMN is high in recipients of autologous hematopoietic stem cell transplantation (aHSCT). Acquisition of genomic mutations represents a key pathogenic driver but the origins, timing and dynamics, particularly in the context of preexisting or emergent clonal hematopoiesis (CH), have not been sufficiently clarified.
View Article and Find Full Text PDFObjectives: The goal of this research was to examine the leadership experiences of senior leaders at the Cleveland Clinic during the recent COVID-19 pandemic crisis. A secondary goal was to examine lessons that could inform other healthcare organisations as they move into subsequent crisis situations.
Design: The authors examined publicly available podcast transcripts where interviewees shared their leadership experiences on the Cleveland Clinic Beyond Leadership Podcast.
Article Synopsis
- - Natural killer (NK) cells’ activity is influenced by killer immunoglobulin-like receptor (KIR) interactions with human leukocyte antigen class I, and this study investigates how somatic mutations in acute myeloid leukemia (AML) relate to outcomes after allogeneic hematopoietic cell transplant (alloHCT).
- - In a study of 81 AML patients who received matched-related donor alloHCT, those with certain somatic mutations and specific KIR profiles experienced less acute graft-versus-host disease (GvHD) but had higher relapse rates, inferior relapse-free survival (RFS), and overall survival (OS).
- - The findings suggest that better NK cell alloreactivity, stemming from a favorable
Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors: An RDSafe Study.
Biol Blood Marrow Transplant
December 2020
Multiple investigations have documented the health-related quality-of-life (HRQoL) and donation-related experiences of unrelated donors (URDs), but similar investigations of the related donor (RD) experience have been less common. The central goal of this study was to longitudinally examine and compare HRQoL of RD and URD hematopoietic stem cell (HSC) donors from predonation through 1 year postdonation. This prospective investigation included adult HSC donors ages 18 to 60 years who donated bone marrow or peripheral blood stem cells at one of 48 geographically diverse US transplant/donor centers and completed HRQoL interviews at predonation and 4 weeks and 1 year postdonation.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how involving clinical genetics during tumor-only next-generation sequencing (NGS) reviews influences the detection of germline alterations, which are important for cancer prevention and treatment.
- - A retrospective analysis showed that over a period from 2013 to 2017, genetic counseling referrals and germline testing increased significantly after implementing genetics involvement in the Molecular Tumor Board reviews.
- - The findings demonstrated that coordinated efforts between genetics services and oncology appointments led to a higher identification rate of germline pathogenic variants, suggesting these processes can enhance cancer management strategies.