Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound.

The presence of senescent cells causes age-related pathologies since their removal by genetic or pharmacological means, as well as possibly by exercise, improves outcomes in animal models. An alternative to depleting such cells would be to rejuvenate them to promote their return to a replicative state. Here we report that treatment of non-growing senescent cells with low-frequency ultrasound (LFU) rejuvenates the cells for growth.

Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective -innate immune interaction.

is one of the most frequent causes of bloodstream infections, and our first line of defense against these invasive infections is the innate immune system. The early immune response is critical in controlling infection, but has several strategies to evade host immune attack. Phagocytosis of blocks hyphal growth, limiting host damage and virulence, but how limits early recruitment and phagocytosis in vertebrate infection is poorly understood.

Strengthening Connections Between the Aging and Disability Networks: Perspectives from the Field.

The aging and disability networks in the United States provide services and supports enabling millions of older adults, people with disabilities, and caregivers to live in the community settings of their choice. With increasing numbers of people with disabilities aging into older adulthood and older adults aging into disability, community living requires seamless and equitable access to services and supports across the aging and disability networks and the life course. This Forum article provides a brief overview of the aging and disability networks and describes successful national initiatives bridging aging and disability organizations such as USAging's Aging and Disability Vaccination Collaborative and the National Aging and Disability Transportation Center.

The Evolving Global Epidemiology of Human Melioidosis: A Narrative Review.

Endemic in over 45 countries globally, recent reports of locally acquired melioidosis in novel geographical areas, such as the Southern US, have highlighted the expanding geographical range of . Climate change and severe weather events have been linked to an increase in cases of melioidosis, which follows environmental exposure to the bacterium. Healthcare professionals should be aware of the possibility of the disease, with its diverse and often delayed presentations, even in areas not previously known to have risk.

Retrograde Thoracic Duct Access for Embolization of Lymphatic Malformations in a Child with Congenital Heart Disease and a Plexiform Thoracic Duct Variant.

The physiologic sequelae of the atypical vasculature in patients with congenital heart disease can result in potentially fatal lymphatic complications, especially after corrective cardiac surgery. Transcatheter embolization of the thoracic duct or lymphatic collaterals can reduce morbidity and mortality in these patients. While typically performed transabdominally via an antegrade approach, retrograde embolization may be preferable in cases where this is not feasible, including in rare variants of thoracic duct anatomy.