Publications by authors named "B J Biemond"
Background: Relapsed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) are associated with a poor prognosis. It is unknown which re-induction therapy provides the highest chance of durable remission. Commonly used therapies are high dose cytarabine (HiDAC) and triple therapy consisting of fludarabine, cytarabine, and idarubicin combined with granulocyte colony-stimulating factor (FLAG-IDA).
View Article and Find Full Text PDFSickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM).
View Article and Find Full Text PDFHemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers.
Res Pract Thromb Haemost
November 2024
Article Synopsis
- The study aimed to investigate how fresh and stored platelet concentrates (PCs) behave during inflammation, specifically in a controlled human model of endotoxemia induced by lipopolysaccharide (LPS).
- Researchers found that LPS increased markers related to coagulation and clotting, leading to a generally lower clotting ability in subjects compared to controls, while platelet transfusions improved clotting time and strength in those with endotoxemia.
- Despite these improvements in coagulation, there were no significant differences noted between the effects of fresh versus stored platelets on coagulation parameters like thrombin-antithrombin complex (TATc) or extracellular vesicles (EVs).