Publications by authors named "B J Arsenault"
Background And Aims: Estimating the genetic risk of coronary artery disease (CAD) is now possible by aggregating data from genome-wide association studies (GWAS) into polygenic risk scores (PRS). Combining multiple PRS for specific circulating blood lipids could improve risk prediction. Here, we sought to evaluate the performance of PRS derived from CAD and blood lipids GWAS to predict the incidence of CAD.
View Article and Find Full Text PDFArticle Synopsis
- Acute pancreatitis (AP) is often triggered by gallstones, alcohol, or high triglycerides, and this study explores the genetic factors that could help identify individuals at higher risk for AP.
- Researchers analyzed genetic data from nearly 485,000 individuals to create a weighted polygenic risk score (PRS) using specific genetic variants linked to pancreatitis.
- Those with a higher pancreatitis PRS (above the 90th percentile) had a significantly increased risk of developing AP, suggesting that this genetic information can aid in identifying patients who might need closer monitoring and intervention.
Background: Maple syrup, a minimally transformed sweetener rich in polyphenols, can exert a action and improve metabolic parameters in animal models. However, no randomized clinical trial has investigated this.
Objectives: This study aims to determine whether replacing refined sugars with an equivalent quantity of maple syrup could decrease key cardiometabolic risk factors in individuals with mild metabolic alterations.
Article Synopsis
- There are currently no drugs available to slow the progression of aortic stenosis, and while plasma lipoprotein(a) levels may predict its onset, their role in disease progression is debated.
- A study involving 710 patients from Canada and the UK examined the relationship between plasma lipoprotein(a) concentrations and hemodynamic changes in aortic stenosis.
- Results showed that patients with higher lipoprotein(a) levels experienced significantly faster progression in peak aortic jet velocity and mean transvalvular gradient, suggesting that elevated lipoprotein(a) may contribute to worse outcomes in aortic stenosis patients.
Background: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS).
Methods: A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from CARTaGENE. A genome-wide PRS including >1.