Publications by authors named "B J Arachchige"
Introduction: , , and are the most medically important species of fish-borne zoonotic trematodes. is endemic to the river plains of Western Siberia and Eastern Europe, and it is estimated that more than 1.6 million people could be infected with this parasite.
View Article and Find Full Text PDFArticle Synopsis
- The primary issue in ALS is the death of motor neurons in the brain and spinal cord, but the exact reasons for this degeneration are still unclear.
- Researchers used SWATH-MS to analyze proteins in the motor cortex of 8 ALS patients compared to 8 healthy controls, identifying 1427 proteins, with 187 showing significant differences in expression.
- Bioinformatics revealed that the altered proteins were linked to various biological processes, with mitochondrial dysfunction identified as a critical pathway that may contribute to motor neuron death in ALS.
Rationale: Severe viral respiratory infections are often characterised by extensive myeloid cell infiltration and activation and persistent lung tissue injury. However, the immunological mechanisms driving excessive inflammation in the lung remain poorly understood.
Objectives: To identify the mechanisms that drive immune cell recruitment in the lung during viral respiratory infections and identify novel drug targets to reduce inflammation and disease severity.
Background: We previously reported that reduced GPR183 expression in blood from tuberculosis (TB) patients with diabetes is associated with more severe TB.
Methods: To further elucidate the role of GPR183 and its oxysterol ligands in the lung, we studied dysglycemic mice infected with Mycobacterium tuberculosis (Mtb).
Results: We found upregulation of the oxysterol-producing enzymes CH25H and CYP7B1 and increased concentrations of 25-hydroxycholesterol upon Mtb infection in the lungs of mice.
Camel milk powder production is an alternative to preserve the perishable milk for later-date consumption. However, the impacts of dehydration processes on bioactive compounds in camel milk are largely unknown. Hence, the present study attempted to compare the physicochemical properties and protein profiles of camel milk powders produced by different concentration and dehydration processes.
View Article and Find Full Text PDF