[Comparison of the results of the treatment of patients with SSPE using various immunomodulating preparations].

The authors analysed the results of controlled treatment by three methods of patients in the 1st or 2nd phase of SSPE in a randomized group. The groups received: I. Propionibacterium granulosum KP-45 (interferon inducer) + isoprinosine, II--TFX (thymus extract) + isoprinosine, III--only isoprinosine.

[Lack of interleukin-1 activity in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis and multiple sclerosis].

Interleukin-1 activity in cerebrospinal fluid of 30 subacute sclerosis panencephalitis and 27 multiple sclerosis patients was measured. ELISA and costimulation thymocyte test revealed no presence of interleukin-1 activity in the cerebrospinal fluid in the tested groups.

[Secretion of tumor necrosis factor alpha (TNF-alpha) by peripheral blood monocytes in patients with multiple sclerosis and subacute sclerosis panencephalitis].

TNF alpha production by peripheral blood monocytes was studied in seventeen patients with a recent exacerbation of MS, thirteen with remission of MS and fourteen patients with SSPE. Monocytes from both MS groups spontaneously secreted high amounts of TNF alpha in vitro. Addition of lipopolisaccharide could not stimulate further synthesis of TNF alpha.

[Subacute sclerosing panencephalitis (SSPE) in Poland 1987-1989. Stage IV of the epidemiological studies].

In the years 1987-1989 111 patients of SSPE who react positively to laboratory tests were found in Poland. The incidence rate of the disease was in 1987-1.30; in 1980-0.

Interleukin 1 and 2 production by peripheral blood mononuclear cells in subacute sclerosing panencephalitis and exacerbation of multiple sclerosis.

Il-1 and Il-2 production by peripheral blood mononuclear cells was studied in 10 patients with SSPE and 15 patients in the acute stage of MS. Both SSPE and MS cells in vitro released spontaneously high amounts of Il-1, and could not be further stimulated to synthesis of Il-1 by latex. The Il-2 production was decreased in both processes but in MS after the recovery from the acute stage the production of Il-2 increased.