Carbamazepine-nefazodone interaction in healthy subjects.

The pharmacokinetic interaction between nefazodone and carbamazepine was investigated in 12 healthy male volunteers. Subjects received nefazodone 200 mg twice daily for 5 days, and blood sample collection was performed on day 5 for 0- to 48-hour pharmacokinetic analysis. A 4-day wash-out phase then followed from days 6 to 9.

Pharmacokinetic evaluation of co-administration of nefazodone and lithium in healthy subjects.

Objectives: To evaluate the possible pharmacokinetic interaction between nefazodone and lithium.

Methods: Twelve healthy volunteers received nefazodone 200 mg b.i.

The kinetic profiles of amlodipine and of a sustained release form of diltiazem.

This study in normotensive subjects compared plasma concentrations of amlodipine (5 mg) and of a sustained release form of diltiazem (300 mg) after single and multiple oral dosings of the two drugs. As a consequence of the galenic form of administered formulations, plasma concentration of diltiazem versus time curves exhibited two peaks corresponding to fast and slow releases of diltiazem. Conversely, the curves of amlodipine plasma concentration depicted only one peak.

Quantitative measurement of BN50727 in human plasma and urine by combined liquid chromatography/negative ion chemical ionization mass spectrometry using a particle beam interface.

A new sensitive assay has been developed for the quantitative measurement of BN50727 at the picomole level in human plasma and urine. The drug and the internal standard (BN50788) were measured by combined liquid chromatography/negative ion chemical ionization mass spectrometry with methane as the reagent gas. A simple solid-liquid extraction procedure was used to isolate BN50727 from the complex biological matrices.

Quantitative measurement of 4-hydroxy tamoxifen in human plasma and mammary tumours by combined gas chromatography/negative chemical ionization mass spectrometry.

A highly sensitive and specific assay was developed for the quantitative measurement of 4-hydroxy tamoxifen (4-OH Tam) at the femtomole level in human plasma and mammary tumours. The drug and deuterated internal standard (4-OH Tam D4) were measured by gas chromatography/negative chemical ionization mass spectrometry with methane as the reactant gas. The two compounds of interest were isolated from the complex biological matrices using a solid-phase extraction procedure with Extrelut 1 columns.