Publications by authors named "B Isgar"
Introduction: The National Institute for Clinical Excellence recommends the use of tumour profiling tests to guide adjuvant chemotherapy in breast cancer. The Oncotype DX™ score (Genomic Health) has superseded more traditional tools such as PREDICT in appropriate patients (ER + ve, HER2-ve, lymph node negative and with a Nottingham Prognostic Index [NPI] ≥ 3.4).
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- MRI is effective in detecting invasive lobular carcinoma (ILC), prompting changes in surgical plans for 26.4% of patients who initially qualified for breast conserving surgery (BCS).
- Most patients (72 out of 334 MRIs) underwent the imaging shortly after their diagnosis, and initial mastectomy rates were 31.9%, increasing to 36.1% after final assessments.
- The study found that MRI correlated better with actual cancer sizes in histopathology than mammograms and ultrasounds, resulting in high rates of disease-free survival (95.8%) and overall survival (98.6%) over a median follow-up of 44 months.