Publications by authors named "B Isermann"
Noncanonical microglial IL-1β maturation in chronic kidney disease.
Nephrol Dial Transplant
November 2024
Background And Hypothesis: Organ transplantation reverses cognitive impairment in chronic kidney disease (CKD), indicating that cognitive impairment driven by CKD is therapeutically amendable. We recently demonstrated that impaired cognition in CKD is linked to IL-1β-release from microglia and IL-1R1-signaling in neuronal cells, thereby identifying a signaling pathway that can be exploited therapeutically. However, the mechanism of IL-1β-maturation in microglia in CKD remains unknown.
View Article and Find Full Text PDFPredicting future kidney allograft function is challenging. Novel biomarkers, such as urinary Dickkopf-3 (uDKK3), may help guide donor selection and improve allograft outcomes. In this prospective multicenter pilot trial, we investigated whether donor uDKK3 reflects organ quality and is associated with future allograft function.
View Article and Find Full Text PDFArticle Synopsis
- - Coagulation factor XII (FXII) is linked to thrombosis and inflammation and is found in increased levels in diabetes and diabetic kidney disease (DKD), but its specific role in DKD was unclear until now.
- - The study reveals that FXII is present in kidney tubular cells, correlating with kidney dysfunction in DKD patients; mice lacking FXII showed protection against kidney damage from high blood sugar.
- - FXII promotes cell damage through a signaling pathway involving uPAR and integrin β1, leading to oxidative stress and cell aging; blocking these pathways may provide new diagnostic and treatment options for DKD and similar diseases.
Article Synopsis
- The study investigates the connection between deep vein thrombosis (DVT) and cerebral ischemia in patients with a patent foramen ovale (PFO), noting a lack of consistent data and screening recommendations in past research.
- Medical records of 339 stroke or transient ischemic attack (TIA) patients with PFO were analyzed, revealing a 7.8% occurrence of DVT, which was associated with several health factors, including a history of DVT, cancer, and specific clinical signs.
- The findings suggest that DVT is common in these patients and recommend using the Wells score as a significant predictor for DVT, guiding further diagnostic tests like compression ultrasonography.