Skin own bacteria may aggravate inflammatory and occlusive changes in atherosclerotic arteries of lower limbs.

Aim: Seroepidemiological studies have given rise to the hypothesis that microorganisms like Chlamydia pneumoniae (CP), Helicobacter pylori (HP), cytomegalovirus (CMV), HCV types 1 and 2, and bacteria involved in dental or other unspecified infection sites may initiate or maintain the atherosclerotic process in lower limb arteries. However, not much attention has been attached to the patient's own limb skin and deep tissues bacterial flora, activated in ischemic tissues. This flora may enhance the inflammatory and thrombotic process in the atherosclerotic arteries.

Traditional eye medication and pterygium occurrence in Limpopo Province.

Background: The relative importance of environmental and hereditary factors in the occurrence of pterygium in African blacks has not been reported.

Aim: To investigate the relative significance of factors associated with pterygium occurrence.

Methods: This was a prospective case-controlled study where 150 pterygium patients and 150 controls participated.

[Genetic factors predisposing to bone fracture non-union. A role of single point mutation Asp299Gly TLR4 on pathogen-evoked healing].

Unlabelled: We previously reported the presence of the bacterial genetic material (16S rRNA) and viable pathogens in fracture gaps specimens, which suggests an impaired pathogen recognition and/or elimination. The aim of study was to validate the hypothesis that patients with delayed bone fracture healing express the higher frequency of TLR4 mutations. Observations were performed in 295 patients treated due to closed fractures of the long bones of the lower extremity; in 151 with delayed bone union (group A), and in 144 with uneventful healing (group B).

Bacteriology of callus of closed fractures of tibia and femur.

Background: More than 1% of closed fractures of lower limbs and 6% of orthopedic implants are complicated by inflammation caused by infection despite of all precautionary methods taken. The question arises whether this clinical complication is not caused by bacteria dwelling in limb tissues.

Methods: Skin, subcutaneous fat, muscle, and fracture gap callus were obtained from 71 adult patients operated on due to closed fractures of tibia or femur; 28 because of comminuted fractures and mal-alignment of bone axis with nonoperative means, and 43 due to delayed healing and unstable union.

Endogeneous sources of infection in transplant recipients.

The mammal organisms carry on their surfaces and in their tissues cohorts of microorganisms of various nature. There is a balance of interests and profits between the host and microbial inhabitants. The bacteria and fungi behave like comensals, colonizers, dormants, however, under certain, mostly unknown, conditions may evoke reaction of the host.