[Dynamics of microsymbiocenoses of upper respiratory tract in normal state and in pathology].

Aim: Study of features of interaction of bacteria in microsymbiocenoses of upper respiratory tract in dynamics in individuals with various state of health: healthy individuals, individuals after tonsillitis and bacteria carriers.

Materials And Methods: Modification of pathogenicity factors (hemolytic, lecitovitellase, lysozyme and anti-lysozyme activity) in intermicrobial interactions of 226 strains of microorganisms isolated during quintuple analysis of upper respiratory tract biocenoses of examined individuals was studied. A hierarchical structure of each microbiocenosis was built based on the data obtained, and its temporal dynamics evaluated.

[Mechanisms of bacteria translocation in generalized chronic parodontitis].

Peculiarities of behavior reactions of bacteria-symbionts created conditions for the selection of translocators-strains. In microsymbiocenosis of parodontal pockets, from which translocation of bacteria into the blood was observed, the number of signals from intermicrobial communication, inhibiting the expression of the factors of colonization, virulence and persistence, was decreasing. Meanwhile, the number of signals on the increase of the expression of the factors given was increased.

[Characteristics of microbiocenosis of gingival pocket in patients with chronic generalized periodontitis].

As a result of examination of 56 patients with chronic generalized periodontitis (CGP) of a moderate severity and a severe form of the disease, microflora from gingival pocket in patients which severe form of CGP was established to have higher specific weight in index of dissemination of strains such as Staphylococcus aureus, Streptococcus pyogencs, Enterococcus, Corynebacterium spp., anaerobic bacteria. Strains from patients with a severe form of CGP were characterized by a higher level of expression of the factors of pathogenicity and persistence.

[Modification of antibiotic resistance in microbial symbiosis].

In antibiotic therapy it is necessary to use drugs active against the pathogen in its association with the host normal microflora. The aim of the study was to investigate modification of antibiotic resistance under conditions of the pathogen association with the representatives of the host normal microflora and to develop the microbiological criteria for determining effectiveness of antibacterials. Modification of microbial antibiotic resistance was investigated in 408 associations.

[Study of nasal and tonsillar mucosal microbiocenoses as one of the health indices].

The qualitative and quantitative compositions of nasal and tonsillar mucosal biocenoses were studied in healthy individuals and patients with chronic tonsillitis as an ecological criterion for assessing the stability of biocenosis and human health. The qualitative composition of tonsillar mucosal biocenosis turned out to be steady-state both in health and disease. The human nasal mucosa showed itself as an indicator system.