Publications by authors named "B Ia Barkane"
Craniofacial morphogenesis is highly complex, as is the anatomical region involved. Errors during this process, resulting in orofacial clefts, occur in more than 400 genetic syndromes. Some cases of cleft lip and/or palate (CLP) are caused by mutations in single genes; however, complex interactions between genetic and environmental factors are considered to be responsible for the majority of non-syndromic CLP development.
View Article and Find Full Text PDFCleft lip with or without cleft palate (CLP and CL, respectively) and isolated cleft palate (CP) represent one of the most common human birth defects, with a prevalence of approximately 1 in 300-2500 depending on the population. Formation of non-syndromic CL/CLP and CP arises from the interaction of environmental and genetic factors. The objective of this study was to investigate the association between the BMP4 gene (encoding bone morphogenetic protein 4) and non-syndromic CL/CLP and CP in order to clarify the role of this gene in the aetiology of the malformation in Latvian and Lithuanian populations.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the genetic and environmental factors contributing to cleft lip and palate (CL/CLP) by analyzing craniofacial data from patients and their parents.
- Researchers evaluated genetic markers in 263 subjects, including 173 patients with CL/CLP/CP and 190 controls, utilizing various statistical methods to determine associations with facial structure.
- Findings indicate that specific genetic markers in the BCL3 gene are linked to craniofacial features, suggesting their significant role in facial development processes.
Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.
Birth Defects Res A Clin Mol Teratol
April 2011
Background: Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common complex birth defect caused by the interaction between multiple genes and environmental factors.
Methods: Five hundred and eighty-seven single nucleotide polymorphisms in 40 candidate genes related to orofacial clefting were tested for association with CL/P in a clefting sample composed of 300 patients and 606 controls from Estonian, Latvian, and Lithuanian populations.
Results: In case-control comparisons, the minor alleles of FGF1 rs34010 (p = 4.
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Birth Defects Res A Clin Mol Teratol
September 2010
Background: Orofacial clefts are among the most common birth defects with a strong genetic component. Nonsyndromic cleft palate (NSCP) is a complex malformation determined by the interaction between multiple genes and environmental risk factors.
Methods: We conducted a case-control association study to investigate the role of 40 candidate genes in predisposition to orofacial clefting.