Publications by authors named "B IONESCU"
Assessment of Total Antioxidant Capacity, 8-Hydroxy-2'-deoxy-guanosine, the Genetic Landscape, and Their Associations in -Negative Chronic and Blast Phase Myeloproliferative Neoplasms.
Mihnea-Alexandru Găman Cristina Mambet Ana Iulia Neagu Coralia Bleotu Petruta Gurban Bogdan Octavian Ionescu
Int J Mol Sci
June 2024
Article Synopsis
- - Myeloproliferative neoplasms (MPNs) like polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) involve excessive production of mature blood cells and can transform into acute myeloid leukemia (sAML), with changes in oxidative stress and antioxidant levels observed.
- - A study measured total antioxidant capacity (TAC) and 8-hydroxy-2'-deoxy-guanosine (8-OHdG) levels in 117 MPN patients and 21 sAML patients versus healthy controls, finding higher TAC levels in MPNs, especially in ET and PMF.
- - The research revealed associations between TAC and
Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire.
Mihnea-Alexandru Găman Robyn Marie Scherber Iulia Ursuleac Ana Manuela Crişan Sorina Nicoleta Bădeliţă Bogdan Octavian Ionescu
J Clin Med
June 2024
Article Synopsis
- A new Romanian version of the MPN Symptom Assessment Form Total Symptom Score (MPN-SAF TSS; MPN-10) was developed to evaluate quality of life (QoL) for patients with myeloproliferative neoplasms (MPNs), addressing their high symptom burden.
- *The study included 180 patients and revealed fatigue, inactivity, and concentration issues as the most problematic symptoms, with notable scoring differences among different MPN subtypes.
- *The Romanian MPN-10 demonstrated strong reliability and validity, indicated by high internal consistency (Cronbach's α = 0.855) and significant psychometric testing results, making it a trustworthy tool for assessing symptom burden and QoL in this patient
The hallmark of acute promyelocytic leukemia (APL) is the presence of the characteristic fusion transcript of the promyelocytic leukemia gene with the retinoic acid receptor α gene (PML::RARA). The PML::RARA fusion is a molecular target for all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Therapies based on ATRA plus ATO have excellent outcomes in terms of complete remission rates, overall survival, and achievement of deep and durable molecular responses with a very low incidence of relapse.
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- Dilated cardiomyopathy (DCM) is a serious heart condition linked to genetic factors, increasing the risk of heart failure and sudden cardiac death; genetic testing plays a crucial role in managing and understanding the disease.
- A study of 122 Romanian patients with DCM revealed that over half (50.8%) had identifiable genetic variants that could cause the disease, along with 31 new variants that had not been reported before.
- The findings indicate that more than half of the patients had a family history of DCM or sudden cardiac death, underscoring the importance of genetic testing for better risk assessment and treatment strategies in this population.
Study on the Possibilities of Developing Cementitious or Geopolymer Composite Materials with Specific Performances by Exploiting the Photocatalytic Properties of TiO Nanoparticles.
Andreea Hegyi Adrian-Victor Lăzărescu Adrian Alexandru Ciobanu Brăduţ Alexandru Ionescu Elvira Grebenişan
Materials (Basel)
May 2023
Article Synopsis
- The paper explores the principles of Sustainable Development and Circular Economy while focusing on the development of materials like cementitious composites and alkali-activated geopolymers.
- It analyzes how different compositional and technological factors impact the physical-mechanical properties, self-healing abilities, and biocidal properties of these materials, particularly enhanced by the addition of TiO nanoparticles.
- The study highlights the increasing interest in these innovative materials but also points out the need for further research to address controversial aspects and promote the integration of improved performance with reduced environmental impacts in building materials.