Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma.

Purpose: We conducted a phase II study evaluating pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin (pembro-GVD) as second-line therapy for relapsed or refractory (rel/ref) classical Hodgkin lymphoma (cHL) (ClinicalTrials.gov identifier: NCT03618550).

Methods: Transplant eligible patients with rel/ref cHL following first-line therapy were treated with two to four cycles of pembrolizumab (200 mg intravenous [IV], day 1), gemcitabine (1,000 mg/m IV, days 1 and 8), vinorelbine (20 mg/m IV, days 1 and 8), and liposomal doxorubicin (15 mg/m, days 1 and 8), given on 21-day cycles.

[Diagnosis of tropical malaria by express-methods].

An examination of a thick blood drop and of blood smear for the presence of plasmodia is a classic and indisputable diagnostic test for tropic malaria. However, express-methods, based on the immune-enzyme analysis, have been introduced into the health-care practice primarily in developing and underdeveloped countries. The diagnosis of tropic malaria by using the discussed methods enables, in the non-laboratory settings, a rapid and reliable detection of PI.

[Modern treatment of malaria].

Ineffectiveness of malaria treatment is in many cases explained by chloroquine resistance (CR) of plasmodia (CRP) which dominates in some regions of Africa and South-East Asia. The authors present their experience in malaria treatment obtained during many years, analyse malaria treatment by new antimalaria drugs in "non-immune" persons temporarily living in endemic regions.

[Clinical significance of cellular and humoral immunity in tropical malaria].

Humoral and cellular immunity were studied in 34, 59 and 21 patients with mild, moderate and severe tropical malaria in the course of the disease. It was found that immunological indices in tropical malaria change with the disease severity. Some immunological indices may be indicative of the infection severity, outcome and prognosis of the disease and contribute to more effective chemotherapy and immunocorrection.