[K-35, a fluorescent probe for albumin study: optical properties].

Fluorescent probe N-(carboxyphenyl)imide of 4-(dimethylamino)naphthalic acid, K-35, is used as an indicator of structural changes of human serum albumin molecules in pathology. The probe occupies albumin binding pockets where the probe environment is of very high polarity; probably, the pocket(s) contains protein polar groups and water molecules. At the same time rather small Stokes shift of K-35 fluorescence spectrum shows that the polar group motion is of one-two order of value lower than mobility of polar molecules in polar fluids.

[Use of a method of recording somatosensory evoked potentials to evaluate the intensity of painful stimulation and the effectiveness of analgesic stimulation].

The authors propose a modified variant of experimental pain stimulation with the attendant registration of somatosensory evoked potentials (EPs) induced by electrocutaneous stimulation via electrodes placed on the ulnar surface of the lower arm. The amplitude of EPs taken from the cranial surface directly correlates with the subjective sensation of pain. These EPs represent superficial positive vibrations with the peak latent period of 240 +/- 23 msec, which are most expressed in leads with saggital electrodes.

[Electrostimulation of the anal sphincter in incontinence among patients with spinal cord lesions].

The effect of electrostimulation of the rectum on the sphincter of the urinary bladder in patients with traumatic damage to the spinal cord and involuntary micturition was studied. It was established that the therapeutic effect of electrostimulation was determined by the parameters of the stimulating current. The optimum parameters were as follows: pulse duration, 0.