Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum.

Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment.

Convergent evolution of oxidized sugar metabolism in commensal and pathogenic microbes in the inflamed gut.

Inflammation-associated perturbations of the gut microbiome are well characterized, but poorly understood. Here, we demonstrate that disparate taxa recapitulate the metabolism of the oxidized sugars glucarate and galactarate, utilizing enzymatically divergent, yet functionally equivalent, gud/gar pathways. The divergent pathway in commensals includes a putative 5-KDG aldolase (GudL) and an uncharacterized ABC transporter (GarABC) that recapitulate the function of their non-homologous counterparts in pathogens.

Sulfate and Dissolved Organic Carbon Concentrations Drive Distinct Microbial Community Patterns in Prairie Wetland Ponds.

Prairie wetland ponds on the Great Plains of North America offer a diverse array of geochemical scenarios that can be informative about their impact on microbial communities. These ecosystems offer invaluable ecological services while experiencing significant stressors, primarily through drainage and climate change. In this first study systematically combining environmental conditions with microbial community composition to identify various niches in prairie wetland ponds, sediments had higher microbial abundance but lower phylogenetic diversity in ponds with lower concentrations of dissolved organic carbon ([DOC]; 10-18 mg/L) and sulfate ([SO ]; 37-58 mg/L) in water.

The Index of Consensual Sexual Sadism (ICSS): Scale development, validation, measurement invariance, and nomological network comparisons with everyday sadism.

Sexual sadism has long been of interest to scholars and clinicians in psychology, and most research on sexual sadism has focused on forensic samples. However, recently, research has uncovered the existence of sexual sadism in general populations. Measures designed to assess sexual sadism in the general population are lacking.

Visual Outcomes and Quality of Vision After Bilateral Implantation of a Hydrophobic Acrylic Trifocal Intraocular Lens.

Purpose: To evaluate visual outcomes and quality of vision following bilateral implantation of a hydrophobic acrylic intraocular lens (IOL) in eyes targeted for emmetropia.

Methods: This was a prospective, single arm study. Subjects were bilaterally implanted with the Clareon PanOptix IOL and evaluated at 1 and 3 months postoperatively.