[Cardiac remodeling in the light of immune status changes in patients with chronic obstructive pulmonary disease].

The degree of structural and functional heart changes was evaluated by means of Doppler echocardiography in 120 patients with chronic obstructive pulmonary disease (COPD) of different degrees of severity. Conventional immunological laboratory techniques were used in all the patients to evaluate the condition of cell-mediated, humoral, and cytokine-mediated immunity; inflammatory process activity and the degree of endotoxicosis were evaluated by measuring blood levels of acute phase proteins and medium mass molecules. The study showed that the character of heart remodeling depended on COPD severity.

[A new method of preparing and some properties of high molecular weight monoamine oxidase from swine liver mitochondria].

Isolation of highly purified and highly molecular monoamine oxidase (MAO) from pig liver mitochondria have been worked out. Specific activity of isolated preparation is 2700 times higher than of original mitochondria homogenate. Enzyme solubilization by digitonin, affinity chromatography purification and ultrafiltration underlie this method.

[Artificial ventilation of the lungs in respiratory failure caused by lesions of the peripheral neuron].

A case with 155-day artificial ventilation of the lungs (AVL) in a patient with the poliencephalomyelitic form of tick-borne encephalitis is described. AVL was conducted through tracheostoma by the Puritan-Bennett 720ae device in the CMU mode for 26 days, then in the SIMU + PS accessory mode for 7 days, and in the CPAP + PS mode for 155 days. Despite the recovery of spontaneous respiration, vital capacity of the lungs did not normalize (1.

[Effects of induction propofol mono-narcosis on the central and cerebral hemodynamics].

Changes in the central hemodynamics were followed up by echocardiography and the linear velocity of the bloodflow by transcranial dopplerography in 15 patients with ASA classes I-II during induction bolus anesthesia with propofol in a dose 2.7 mg/kg without opioids. The diastolic and mean arterial pressure decreased by 12.

[Amine oxidase from the bacterial strain Methanosarcina barkeri 27].

A new source of the enzyme amine oxidase (AO), namely bacteria of Methanosarcina barkery 27 strain, was discovered. The method AO isolation and purification from the bacteria was developed and the enzyme substrate and inhibitory specificity was studied. Contrary to some other microbial amine oxidases the AO investigated was shown to determine benzylamine and serotonin along with tyramine, all these substrates being deaminated at the equal rate.