Publications by authors named "B I Blum"
Repeated antigen exposure leads to T-cell exhaustion, a transcriptionally and epigenetically distinct cellular state marked by loss of effector functions (e.g., cytotoxicity, cytokine production/release), up-regulation of inhibitory receptors (e.
View Article and Find Full Text PDFTranscriptional induction coincides with the formation of various chromatin topologies. Strong evidence supports that gene activation is accompanied by a general increase in promoter-enhancer interactions. However, it remains unclear how these topological changes are coordinated across time and space during transcriptional activation.
View Article and Find Full Text PDFHigh-sensitivity nanoflow liquid chromatography (nLC) is seldom employed in untargeted metabolomics because current sample preparation techniques are inefficient at preventing nanocapillary column performance degradation. Here, we describe an nLC-based tandem mass spectrometry workflow that enables seamless joint analysis and integration of metabolomics (including lipidomics) and proteomics from the same samples without instrument duplication. This workflow is based on a robust solid-phase micro-extraction step for routine sample cleanup and bioactive molecule enrichment.
View Article and Find Full Text PDFArticle Synopsis
- Meckel's diverticula are common gastrointestinal anomalies, but mesodiverticular bands are rare and typically require surgical treatment.
- A healthy 20s patient experienced acute abdominal pain, and imaging revealed a large intestine volvulus due to a mesodiverticular band connecting the ileal mesentery and a Meckel's diverticulum.
- The patient had surgery, successfully underwent resection, and recovered well; mesodiverticular bands can cause serious issues like hemoperitoneum, small bowel obstruction, and volvulus but are often diagnosed during surgery.