Publications by authors named "B Holt"
Cyclosporine A combined with mycophenolate mofetil (CsA/MMF) has become an established regimen for the prevention of graft-versus-host disease (GVHD) following non-myeloablative (NMA) allogeneic hematopoietic stem cell transplantation (alloHSCT). However, the optimal duration of immunosuppression (IS) has not yet been defined and overtreatment is of concern. We hypothesized that time-restricted IS with CsA/MMF would increase the proportion of patients with non-severe GVHD compared to standard-duration IS, thereby resulting in reduction of the relapse rate and improvement of progression-free survival (PFS) and overall survival (OS).
View Article and Find Full Text PDFRituximab maintenance for patients with diffuse large B-cell lymphoma in first complete remission: Long-term results of the HOVON-84 randomized phase III study by the HOVON and the Nordic Lymphoma Group (clinical trial number: NTR1014).
Pieternella Johanna Lugtenburg Peter de Nully Brown Bronno van der Holt Eva de Jongh Josée M Zijlstra
Eur J Cancer
January 2025
Article Synopsis
- Pompe disease results from a deficiency in acid alpha-glucosidase, leading to muscle weakness, respiratory issues, and cardiomyopathy in infants; the only current treatment is enzyme replacement therapy (ERT).
- A new approach using a Centyrin protein-conjugated short interfering RNA (siRNA) targets the transferrin receptor (CD71) and the GYS1 enzyme to inhibit glycogen synthesis, potentially restoring glycogen balance instead of just degrading it.
- In tests on a Pompe mouse model, this novel siRNA conjugate effectively reduced GYS1 levels and glycogen accumulation, improving exercise performance, indicating its promise as a therapy for late-onset Pompe disease or in combination with ERT for infants.
Article Synopsis
- Crohn's disease strictures are typically managed with a single endoscopic balloon dilation (EBD), but researchers explored the effectiveness of repeat EBD combined with needle-knife stricturotomy (NKSt) alongside aggressive drug therapy.
- In a study of 21 patients, those receiving intensive treatment (multiple EBDs and/or NKSt) showed a higher symptom improvement rate (72%) compared to those with a single EBD (40%).
- The findings suggest that repeat dilations and NKSt are safe and potentially more effective for treating strictures, especially when paired with enhanced drug treatment for inflammation.