Publications by authors named "B Hibbert"
Background: Up to 50% of patients undergoing mitral transcatheter edge-to-edge repair (MTEER) have an indication for left atrial appendage occlusion (LAAO). However, prospective evaluation of this strategy is lacking.
Objectives: The aim of the study was to prospectively evaluate the outcomes of combined LAAO and MTEER.
Utility of Noninvasive Testing Before Invasive Coronary Angiography in the Assessment for Revascularization.
Mayo Clin Proc Innov Qual Outcomes
February 2025
Objective: To examine the role of noninvasive testing (NIT) before invasive coronary angiography (ICA) by evaluating the association between a positive myocardial perfusion imaging (MPI) or computed tomography angiography (CTA) result and the decision to perform coronary revascularization.
Patients And Methods: We screened all patients who received ICA between August 1, 2015, and July 31, 2019, and identified those who received MPI or CTA within the preceding 12 months. We considered MPI to be a positive result if it found moderate or severe ischemia in a specific coronary territory and CTA to be a positive result if it identified a stenosis greater than 50% in any major coronary artery.
Background: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, making it challenging to predict patient trajectory and response to treatment. This study aims to identify biological/molecular CS subphenotypes, evaluate their association with outcome, and explore their impact on heterogeneity of treatment effect (ShockCO-OP, NCT06376318).
Methods: We used unsupervised clustering to integrate plasma biomarker data from two prospective cohorts of CS patients: CardShock (N = 205 [2010-2012, NCT01374867]) and the French and European Outcome reGistry in Intensive Care Units (FROG-ICU) (N = 228 [2011-2013, NCT01367093]) to determine the optimal number of classes.
Article Synopsis
- Currently, intravascular optical coherence tomography (IV-OCT) is primarily used for imaging the structure of arterial plaques, but it lacks the ability to detect molecular changes in the endothelium, which could improve risk assessment for cardiovascular issues.
- Researchers developed gold superclusters (AuSCs) that are designed to enhance IV-OCT by increasing light scattering and targeting specific molecules in the vascular system.
- In tests with a rat model, these AuSCs successfully enabled molecular imaging of vascular inflammation by correlating the imaging signal with the severity of inflammation, demonstrating potential for earlier detection of cardiovascular risks.