[Clinical benefits of stabilization after second-line chemotherapy in patients with metastatic colorectal cancer].

New innovative cytotoxic agents have proven active for treating patients with metastatic cancer who have failed first line 5FU based therapy, with sizeable objective response rates and a much higher rate of stabilization. The benefit of stabilization has not yet been well evaluated. A prospective multicentric study was carried out with 80 patients treated by second line chemotherapy for metastatic colorectal cancer.

Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever.

Objective: We compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6-24 months in an open, randomised study with three parallel groups.

Methods: The main criterion for efficacy was area under the curve (AUC) of percentage temperature reduction.