Publications by authors named "B Henninger"
: Anemia is a frequent multifactorial co-morbidity in end-stage kidney disease (ESKD) associated with morbidity and poor QoL. Apart from insufficient erythropoietin formation, iron deficiency (ID) contributes to anemia development. Identifying patients in need of iron supplementation with current ID definitions is difficult since no good biomarker is available to detect actual iron needs.
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- Early studies suggested that iron accumulation occurs in Friedreich's ataxia (FA), but data from actual patients was limited, prompting further investigation into systemic iron metabolism and regulation in FA patients.
- The study involved 40 FA patients and matched healthy controls, analyzing serum iron parameters, hormones, and iron distribution in blood cells, while also using MRI to assess iron stores in organs like the liver and spleen.
- Results indicated that FA patients had lower serum iron levels and certain iron-related proteins correlated inversely with genetic severity; there was also an unexpected discovery of iron deficiency and altered iron distribution within cells, suggesting that systemic iron-lowering treatments might not be ideal for FA patients.
Background: Aortic stenosis (AS) is one of the most prevalent valvular heart-diseases in Europe. Currently, diagnosis and classification are not sex-sensitive; however, due to a distinctly different natural history of AS, further investigations of sex-differences in AS-patients are needed. Thus, this study aimed to detect sex-differences in severe AS, especially concerning flow-patterns, via phase-contrast cardiac magnetic resonance imaging (PC-CMR).
View Article and Find Full Text PDFBackground: Dysglycaemia increases the risk of myocardial infarction and subsequent recurrent cardiovascular events. However, the role of dysglycaemia in ischemia/reperfusion injury with development of irreversible myocardial tissue alterations remains poorly understood. In this study we aimed to investigate the association of ongoing dysglycaemia with persistence of infarct core iron and their longitudinal changes over time in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).
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