Publications by authors named "B Heissig"
MicroRNAs, including the tumor-suppressor miR-126 and the oncogene miR-221, regulate tumor formation and growth in colitis-associated cancer (CAC) and colorectal cancer (CRC). This study explores the impact of the epithelial cytokine heparin-binding epidermal growth factor (HB-EGF) and its receptor epidermal growth factor receptor (EGFR) on the pathogenesis of CAC and CRC, particularly in the regulation of microRNA-driven tumor growth and protease expression. In murine models of CRC and CAC, lack of miR-126 and elevated miR-221 expression in colonic tissues enhanced tumor formation and growth.
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- PAI-1 is associated with blood clotting issues and endothelial dysfunction in severe COVID-19, and certain genetic variations can affect its expression.
- Clinical studies on COVID-19 patients found that while comorbidities didn’t correlate with specific genotypes, the 4G/5G polymorphism showed differences in fibrinolytic factors and IL-1β levels.
- The 4G4G genotype was linked to high PAI-1 levels and suppressed fibrinolysis, while inflammation-related endothelial dysfunction was a risk for those with the 5G5G genotype.
Treatment resistance after chemo-/immunotherapy occurs in patients with head and neck squamous cell cancers (HNSCs), including salivary gland cancers (SGCs). Interleukin-10 (IL-10), a cytokine with pro- and anti-cancer effects, has an unclear impact on HNSC/SGC cells. We show that HNSC patients exhibiting high expression of IL-10 and its receptor IL-10Rα experience have prolonged overall survival.
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- COVID-19 patients face a higher risk of thrombosis and acute respiratory distress syndrome (ARDS) due to changes in blood-clotting factors, specifically increased PAI-1 and decreased uPA.
- A study of 69 hospitalized COVID-19 patients revealed that elevated free PAI-1 and low uPA levels correlated with disease severity and the onset of ARDS.
- The findings suggest that uPA and its complex with PAI-1 could serve as valuable biomarkers for identifying patients at risk for severe COVID-19 and ARDS.