Long-lasting pigment fixation of ancient paintings using hydrophilic microgels prepared from hydroxyethyl cellulose and sodium alginate.

The long-term fixation of mineral pigments in ancient paintings has always been a challenge. Gelatin alum solution (GAW), as a traditional pigment fixative, presents good pigment fixation in the early stage of use, but its poor durability is well known. In this work, a microgel (SH) prepared from sodium alginate and hydroxyethyl cellulose was proposed to replace GAW for the pigment fixation due to its micro scale, strong adhesion, and good chemical stability.

Transarterial chemoembolization versus hepatic arterial infusion chemotherapy as first treatment for hepatocellular carcinoma with macrovascular invasion.

Transarterial chemoembolization (TACE) is an optional treatment for hepatocellular carcinoma (HCC) patients with macrovascular invasion (MVI) and without extrahepatic metastasis (EHM). As a recently emerging approach, the efficacy of hepatic arterial infusion chemotherapy (HAIC) compared with TACE in this group of patients is unclear. Between December 2016 and June 2020, patients diagnosed with HCC with MVI and without EHM who underwent TACE (n=91) or HAIC (n=190) as their initial treatment were included.

Chiral Phosphoric Acid Catalyzed Asymmetric Mannich Reaction of 2-Aryl-3-indol-3-ones with α-H Diazoacetates.

An asymmetric Mannich reaction between 2-aryl-3-indol-3-ones and α-H diazoacetates catalyzed by chiral phosphoric acid was developed. This strategy achieves the effective synthesis of chiral 2,2-disubstituted indolin-3-ones bearing a quaternary stereocenter and containing a diazo group in the C2 substituent (up to >99% ee and 82% yield). To demonstrate the importance of the synthesized 2,2-disubstituted indolin-3-ones and the diversity of their diazo group reactions, we successfully achieved the relevant transformation reactions with a diazo group (such as hydroxylation, hydrogenation, intramolecular cyclization, etc.

Royal Jelly Enhances the Social Status of Submissive Rats by Restoring Balance to the Disturbed Gut-Brain Communication.

Royal jelly (RJ) has long been considered a crucial dietary component in dictating caste differentiation in honeybees. As a nutritional additive, royal jelly imparts a broad range of benefits to mammals and humans; however, its precise impact on the social hierarchy of these advanced animals is not yet fully understood. This study aims to determine whether the benefits of royal jelly can be transferred to rats to alter their social ranks and uncover the underlying mechanisms.

Effects of Deoxynivalenol Detoxifier on Growth Performance, Blood Biochemical Indices, and Microbiota Composition of Piglets.

Deoxynivalenol (DON), also known as vomitoxin, has a high detection and exceeding rate in feed and is prone to causing symptoms such as loss of appetite, weight loss, vomiting, and diarrhoea in animals, which brings great harm to the aquaculture industry. The common mycotoxin adsorbents have low adsorption rates for DON, and the use of biological methods to remove DON in feeds has gradually become a research trend. One hundred and twenty crossbred barrows were randomly divided into four groups, which included the normal diet group (CON), normal diet + detoxifier group (Det), DON-polluted diet group (DON), and DON-polluted diet + DON detoxifier group (DON + Det); the experiment lasted for 28 d.