Response of stratospheric water vapour to warming constrained by satellite observations.

Future increases in stratospheric water vapour risk amplifying climate change and slowing down the recovery of the ozone layer. However, state-of-the-art climate models strongly disagree on the magnitude of these increases under global warming. Uncertainty primarily arises from the complex processes leading to dehydration of air during its tropical ascent into the stratosphere.

[Perceived restrictions during the COVID-19 pandemic by older persons in Switzerland].

Background: The current coronavirus pandemic has had various effects on older people's everyday lives. Within the framework of pandemic-related protective measures, people over 65 years of age in particular were asked to stay away from public places and avoid direct physical contact.

Aim: This paper examines how the pandemic affected the feelings of people over 50 years of age with regard to the limited daily supply of everyday things, outdoor physical activity and social contact.

Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model.

Imbalance in cellular ionic homeostasis is a hallmark of several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS). Sodium-calcium exchanger (NCX) is a membrane antiporter that, operating in a bidirectional way, couples the exchange of Ca and Na  ions in neurons and glial cells, thus controlling the intracellular homeostasis of these ions. Among the three NCX genes, NCX1 and NCX2 are widely expressed within the CNS, while NCX3 is present only in skeletal muscles and at lower levels of expression in selected brain regions.

Impact of the COVID-19 Pandemic on Loneliness Among Older Adults.

The COVID-19 pandemic has created a pattern of everyday physical distancing worldwide, particularly for adults aged 65+. Such distancing can evoke subjective feelings of loneliness among older adults, but how this pandemic has influenced that loneliness is not yet known. This study, therefore, explored the association between subjective loneliness and different time phases of the COVID-19 pandemic to explain the pandemic's impact on loneliness among older adults.

The intention to use HIV-pre-exposure prophylaxis (PrEP) among men who have sex with men in Switzerland: testing an extended explanatory model drawing on the unified theory of acceptance and use of technology (UTAUT).

Aim: The aim of this study was to determine the intention to use pre-exposure prophylaxis (PrEP) when available and to identify predictors of the intention to use PrEP among men who have sex with men (MSM) living in Switzerland. The theoretical model drew on the Unified Theory of Acceptance and Use of Technology and considered additional variables related specifically to PrEP, HIV protection and the resources of MSM.

Subject And Methods: For data collection, we used an anonymous, standardized self-administered online questionnaire.