Publications by authors named "B Halwachs"

ATGL is a key enzyme in intracellular lipolysis and plays an important role in metabolic and cardiovascular diseases. ATGL is tightly regulated by a known set of protein-protein interaction partners with activating or inhibiting functions in the control of lipolysis. Here, we use deep mutational protein interaction perturbation scanning and generate comprehensive profiles of single amino acid variants that affect the interactions of ATGL with its regulatory partners: CGI-58, G0S2, PLIN1, PLIN5 and CIDEC.

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Klebsiella spp. that secrete the DNA-alkylating enterotoxin tilimycin colonize the human intestinal tract. Numbers of toxigenic bacteria increase during antibiotic use, and the resulting accumulation of tilimycin in the intestinal lumen damages the epithelium via genetic instability and apoptosis.

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Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding. ADAM17 is involved in the processing of multiple substrates including tumor necrosis factor (TNF) α and EGF receptor ligands.

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Article Synopsis
  • - The study investigates the effectiveness of fecal microbiota transplantation (FMT) in treating acute graft-versus-host disease (GvHD) of the lower GI tract in patients who do not respond to standard treatments, revealing that 4 out of 9 patients showed a positive response with increased survival.
  • - The findings highlight that the use of broad-spectrum antibiotics before or during FMT is linked to treatment failure and negatively impacts the establishment of donor microbiota in responders.
  • - An analysis of immune cell composition showed significant shifts in the types of immune cells present in the gut post-FMT, particularly a decrease in immunomodulatory cells, suggesting that successful FMT alters immune responses in patients with refractory GI-GvHD. *
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Molecular techniques including the sequencing of fungal-specific DNA targets are increasingly used in the diagnosis of suspected invasive fungal infections. In contrast to established biomarkers like galactomannan or 1-3-β-d-glucan, the clinical impact of these methods remains unknown. We retrospectively investigated the impact of ITS1-sequencing on antifungal treatment strategies in 71 patients (81 samples) with suspected invasive fungal infections.

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