Publications by authors named "B Hagos"
Article Synopsis
- Diarrhea is a significant health issue in Ethiopia, particularly in the Amhara Regional State, where the prevalence rate among children under-five is reported at 17.7%.
- The study used statistical methods, including multivariable logistic regression, to identify key risk factors associated with diarrhea, such as child gender, mother's education level, and family size.
- Findings indicate that having a male child, a mother with no education, and being in a larger family are linked to a higher risk of diarrhea in young children, with the rates in Amhara being notably higher than the national average.
Cell state control is crucial for normal tissue development and cancer cell mimicry of stem/progenitor states, contributing to tumor heterogeneity, therapy resistance, and progression. Here, we demonstrate that the cell surface glycoprotein Mcam maintains the tumorigenic luminal progenitor (LP)-like epithelial cell state, leading to Basal-like mammary cancers. In the Py230 mouse mammary carcinoma model, Mcam knockdown (KD) destabilized the LP state by deregulating the Ck2/Stat3 axis, causing a switch to alveolar and basal states, loss of an estrogen-sensing subpopulation, and resistance to tamoxifen-an effect reversed by Ck2 and Stat3 inhibitors.
View Article and Find Full Text PDFBackground: In Ethiopia, the mortality rate for children under five is a public health concern. Regretfully, the problem is notably underestimated and underreported, making it impossible to fully recognize how serious the situation is in the nation's developing regions. Unfortunately, no single study has been conducted to reveal the rates and predictor factors of under-five child death in Ethiopia's pastoral regions.
View Article and Find Full Text PDFArticle Synopsis
- Ethiopia has a low usage rate of modern contraceptive methods, particularly among its nomadic tribes, prompting a study to explore the factors influencing their adoption.
- A retrospective cross-sectional study was conducted on a sample of 3,415 nomadic women, using data from the 2016 Ethiopian Demography and Health Survey and employing multivariable logistic regression to analyze the results.
- The study found that only 10% of respondents used modern contraceptives, mainly injections, and highlighted critical predictors for usage including husbands' education level, wealth status, access to public health facilities, and work status.
Breast cancers are categorized into subtypes with distinctive therapeutic vulnerabilities and prognoses based on their expression of clinically targetable receptors and gene expression patterns mimicking different cell types of the normal gland. Here, we tested the role of Mcam in breast cancer cell state control and tumorigenicity in a luminal progenitor-like murine tumor cell line (Py230) that exhibits lineage and tumor subtype plasticity. Mcam knockdown Py230 cells show augmented Stat3 and Pi3K/Akt activation associated with a lineage state switch away from a hormone-sensing/luminal progenitor state toward alveolar and basal cell related phenotypes that were refractory to growth inhibition by the anti-estrogen therapeutic, tamoxifen.
View Article and Find Full Text PDF