Dedifferentiated parosteal osteosarcoma with a novel low-grade leiomyosarcomatous and high-grade conventional osteosarcomatous differentiation: Case report and review of literature.

Introduction & Importance: Parosteal osteosarcoma is an uncommon, low-grade, well differentiated malignant bone neoplasm with a more favorable prognosis compared to other types of osteosarcoma. Dedifferentiation is a well-known phenomenon, observed in 16-24.6 % of cases, leads to a combination of low-grade fibroblastic osteosarcoma and high-grade sarcoma.

Huge Atypical Meningioma in a 21-Month-Old Girl: A Case Report.

Meningiomas are the most common intracranial tumors, but it's uncommon in the pediatric and adolescent populations. Pediatric meningiomas differ from adult meningiomas by a higher rate of malignant change, atypical location, male predominance and a higher recurrence rate. The most common presenting symptoms in supratentorial pediatric meningiomas are the signs and symptoms of high intracranial pressure (headache, vomiting, and nausea) and seizures.

A Systematic Review of Questionnaires Assessing Patient Satisfaction in Plastic Surgery: Tools, Topics, and Surgical Types.

Background: Patient satisfaction is crucial for evaluating healthcare services, including plastic surgery. This systematic review aims to analyze questionnaires assessing patient satisfaction in plastic surgery, identifying their strengths and weaknesses to improve outcomes and enhance the quality of care.

Methods: A comprehensive literature search was conducted using electronic databases.

Interosseous Malignant Melanotic Nerve Sheath Tumor of the Sacrum Treated With an Innovative Reconstruction Technique.

Intraosseous malignant melanotic nerve sheath tumors are extremely uncommon peripheral nerve sheath tumors that typically present with benign clinical and histopathological features but with more aggressive long-term behavior. These tumors commonly originate from the dorsal nerve roots, sympathetic chain, cranial nerves, and lumbar plexus but may be found throughout the body. It usually presents with gradual compressive symptoms over months to years, like the typical presentation of schwannomas.

The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory.

Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (-promoter methylation, and protein methyltransferase proteins-5 ( activity, with tumor progression has never been described.

Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors.