Conjunctival Metastasis of a Cutaneous Melanoma.

Purpose: To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies.

Methods: Clinical and histopathological examination of the conjunctival lesion.

Squamous cell carcinoma of the lacrimal caruncle: case reports.

Purpose: To report 2 cases of squamous cell carcinoma of the lacrimal caruncle.

Methods: Two patients, a 38-year-old man and a 72-year-old woman, presented with a painful mass in the medial angle of the eyelid aperture, with signs of inflammation. Biopsy was performed in both cases.

Long-term outcomes of eye-conserving treatment with Ruthenium(106) brachytherapy for choroidal melanoma.

Purpose: To evaluate long-term outcomes of eye-conserving treatment using Ruthenium-106 plaque brachytherapy with or without transpupillary thermotherapy (TTT) for small to intermediate size choroidal melanomas.

Methods: Outcomes of 425 consecutive patients were analysed. The median basal tumour diameter was 10.

[The first gender-changing operation from female to male in The Netherlands, 1959/'60].

The first sex-change operation in a transsexual patient, i.e. the construction of a penis (so-called phalloplasty), took place in the Netherlands in Arnhem in 1959-1960.