beta-Endorphin and natural killer cell cytolytic activity during prolonged exercise. is there a connection?

This study was designed to test whether a single 50-mg dose of the opioid antagonist naltrexone hydrochloride, ingested 60 min before 2 h of moderate-intensity exercise (i.e., 65% peak O2 consumption), influenced the exercise-induced augmentation of peripheral blood natural killer cell cytolytic activity (NKCA).

Effect of melarsoprol treatment on circulating IL-10 and TNF-alpha levels in human African trypanosomiasis.

The pathogenesis of human African trypanosomiasis (HAT) has been the object of considerable research interest but has remained incompletely understood. The importance of cytokines in the pathophysiology of this protozoan infection is now widely recognized, but the full spectrum of cytokines involved has yet to be determined. In the present investigation we compared the plasma concentrations of TNF-alpha and IL-10 in normal African controls and patients suffering from advanced meningocephalic (late-stage) Trypanosomiasis brucei (T.

Strenuous exercise and immunological changes: a multiple-time-point analysis of leukocyte subsets, CD4/CD8 ratio, immunoglobulin production and NK cell response.

This study was designed to examine the impact of exhaustive endurance exercise on a number of immune parameters of physically fit male subjects (VO2max 66.5 +/- 5.3 ml/min/kg) who performed treadmill exercise at 65% of their VO2max for 120 min.

Neuroendocrine regulation of immune processes: change in circulating corticosterone levels induced by the primary antibody response in mice.

The induction of antibody formation mediated significant changes in circulating corticosterone (CS) levels in mice. On the day of the peak plaque-forming cell (PFC) response to sheep red blood cells (SRBC) or to the trinitrophenyl (TNP) hapten, the 0800 h serum CS concentration was increased. This hormonal elevation was not observed in SRBC-immunized low responder animals which did not give a significant PFC response, thus suggesting a direct correlation between immune responsiveness and hormonal changes.

Immune response mediated by liposome-associated protein antigens. II. Comparison of the effectiveness of vesicle-entrapped and surface-associated antigen in immunopotentiation.

The immunogenicity of different preparations of liposome-associated bovine serum albumin (LSM-BSA) was compared in order to examine the significance of the site of association between a protein antigen and the liposomal carrier. Animals immunized with liposomes containing both entrapped and surface-adsorbed BSA. (LSM-BSA) e + a, were found to give a BSA-specific plaque-forming cell (PFC) response comparable with that elicited by animals immunized with trypsinized (LSM-BSA) e + a which contained mainly entrapped BSA.