Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer.

The negatively charged aminophospholipid, phosphatidylserine (PS), is typically restricted to the inner leaflet of the plasma membrane under normal, healthy physiological conditions. PS is irreversibly externalized during apoptosis, where it serves as a signal for elimination by efferocytosis. PS is also reversibly and transiently externalized during cell activation such as platelet and immune cell activation.

Unveiling the potential of tankyrase I inhibitors for the treatment of type 2 diabetes mellitus: A hybrid approach using network pharmacology, 2D structural similarity, molecular docking, MD simulation and in-vitro studies.

Aims: This study explores the association between the Wnt signaling pathway and T2DM, emphasizing the role of Tankyrase1 (TNKS1) in metabolic regulation. Using network pharmacology and computational approaches, it aims to identify potential FDA-approved drugs for repurposing as Wnt inhibitors to improve insulin sensitivity and reduce fat accumulation.

Materials And Methods: Network pharmacology analysis was performed to explore the association between the Wnt pathway and T2DM, identifying Catenin Beta 1 (CTNBB1) as a key hub gene involved in disease progression.

Discovery of novel benzoxazole analogues as potential anticancer agent selectively targeting aromatase.

Estrogen play an important role in the development of breast cancer in menopausal women. Aromatase, an enzyme that catalyses the last step in the production of estrogen, has been identified as a promising target for clinical development. In the present investigation, novel 2-substituted benzoxazoles were synthesized and evaluated for inhibition against aromatase.

Combined Petrosal Approach With Transcochlear Extension for Fisch D Jugular Paraganglioma: A Technical Case Report.

Background And Importance: Surgery for jugular paragangliomas (JPs) is known to be a formidable challenge because of the tumor's intimate involvement of neurovascular structures. Although radiosurgery is commonly the first-line treatment, recent advances in neuroimaging, surgical techniques, and intraoperative monitoring have positioned surgery as a feasible alternative for aggressive tumors with substantial intradural extension not amenable to upfront radiosurgery, provided the surgeon has an in-depth knowledge of lateral skull-base anatomy and access to safe and effective preoperative embolization.

Clinical Presentation: A patient with a Fisch Type D JP with extensive intradural tumor and brainstem compression underwent a combined petrosal approach with transcochlear extension at our institution.

Higher Rates of Hypersensitivity Reactions to Calaspargase Compared With Pegaspargase: A Single Center Retrospective Review.

Background: Asparaginase is a critical component of curative therapy for the treatment of pediatric acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). Pegaspargase (PEG) increased the duration of asparagine depletion and lowered the incidence of hypersensitivity reactions (HSRs) compared with native asparaginase. When a second pegylated product, Calasparagase pegol-mknl (Cal-PEG) replaced PEG, we observed an increased incidence of HSR, defined as anaphylaxis or silent hypersensitivity.