Publications by authors named "B H Hartley"
Objectives: To explore pain outcomes in patients prescribed hydrocodone and psychotropic medications with or without CYP2D6 inhibition activity.
Methods: Patients hospitalized for lower/limited upper extremity injuries who were prescribed hydrocodone alongside a psychotropic medication were considered for this study (n=224). A subset of these patients (n=178) was prescribed a psychotropic medication known to inhibit CYP2D6, while the remainder (n=46) were prescribed psychotropic medications without CYP2D6 inhibition activity.
Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting 80% of cytosolic proteins in humans. The human essential gene, encodes the enzyme NAA10, as the catalytic subunit for the N-terminal acetyltransferase A (NatA) complex, including the accessory protein, NAA15. The first human disease directly involving was discovered in 2011, and it was named Ogden syndrome (OS), after the location of the first affected family residing in Ogden, Utah, USA.
View Article and Find Full Text PDFComprehensive management and classification of first branchial cleft anomalies: An International Pediatric Otolaryngology Group (IPOG) consensus statement.
Int J Pediatr Otorhinolaryngol
November 2024
Article Synopsis
- First branchial cleft anomalies are rare issues in the head and neck area that some kids are born with, and there's not much info on how to classify or treat them properly.
- * Expert doctors worked together to come up with better ways to identify and manage these anomalies using a method called the Delphi method.
- * They created a new classification system and treatment guidelines to help doctors give better care to kids with these conditions.
Article Synopsis
- Accurately determining the dose-response relationship is essential in drug development, and using longitudinal data from multiple timepoints can improve estimation efficiency over using just one timepoint.
- Optimal design theory helps compare different study designs, revealing that models using longitudinal data can reduce necessary sample sizes by 30% to 55%.
- Fractional polynomials provide a flexible method for analyzing repeated measurements in dose-response studies, maintaining robustness and substantial efficiency gains even when the true model is mis-specified.
Fecal microbiota transplantation (FMT) is the administration of fecal bacteria from a healthy donor into the intestinal tract of a recipient in order to directly change the recipient's gut microbial composition and confer a health benefit. The relationship between the gut microbiome and the central nervous system, termed the gut-brain axis, has been a frequent topic of gut microbiome studies. Commensal gut bacteria communicate with the central nervous system through various hormones, cytokines, and neural pathways.
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