Publications by authors named "B H Hahn"
Background: Lower extremity lymphedema (LEL) can develop because of inguinal lymph node dissection in the treatment of gynecologic, genitourinary, and dermatological malignancies. To optimize patient counseling and patient selection for microsurgical interventions aimed at preventing or treating LEL, its prevalence and associated patient characteristics must be accurately documented. This systematic review and meta-analysis provides a comprehensive overview of literature on the reported prevalence of LEL in patients undergoing inguinal lymphadenectomy.
View Article and Find Full Text PDFEliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine research. We characterized Ab1456 and Ab1271, two heterologously-neutralizing antibodies elicited in non-human primates by priming with an engineered V3-targeting SOSIP Env immunogen and boosting with increasingly native-like SOSIP Envs derived from different strain backgrounds. Structures of Env trimers in complex with these antibodies revealed V3 targeting, but on conformational states of Env distinct from the typical closed, prefusion trimeric SOSIP structure.
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- The study focused on the effectiveness of free tissue transplants in treating complex lower extremity defects, comparing outcomes from fasciocutaneous flaps and muscle flaps among patients.
- Data from 206 eligible patients over several years indicated no significant differences in functionality or quality of life between the two flap types, though pain notably affected outcomes for both.
- Key factors impacting patient-reported outcomes included obesity, diabetes, and mental health, suggesting that flap selection should consider these individual patient characteristics.
Genes encoded within organelle genomes often evolve at rates different from those in the nuclear genome. Here, we analyzed the relative rates of nucleotide substitution in the mitochondrial, apicoplast, and nuclear genomes in four different lineages of Plasmodium species (malaria parasites) infecting mammals. The rates of substitution in the three genomes exhibit substantial variation among lineages, with the relative rates of nuclear and mitochondrial DNA being particularly divergent between the Laverania (including Plasmodium falciparum) and Vivax lineages (including Plasmodium vivax).
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- The study aimed to assess the survival and clinical quality of individually layered indirect composite restorations (ICRs) in patients aged 6 to 50 across two locations, focusing on outcomes from 2008 to 2018.
- A total of 155 restorations were evaluated, revealing high success rates of 95.4% at 1 year, 87.4% at 5 years, and 78.8% at 10 years, with over 90% rated as excellent or good in clinical quality.
- While the restorations demonstrated strong success, restored teeth had more plaque buildup compared to unrestored teeth, indicating a notable difference in periodontal health.