Publications by authors named "B H HYUN"
Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy. Although the role of the UPS and autophagy in slowing age-induced proteostasis decline has been elucidated, limited information is available on how these pathways can be activated in a collaborative manner to delay proteostasis-associated aging. Here, we show that activation of the UPS via the pharmacological inhibition of USP14 (ubiquitin specific peptidase 14) using IU1 improves proteostasis and autophagy decline caused by aging or proteostatic stress in and human cells.
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- A 20-year study (2001-2020) in Jangmok Bay, Korea, examined how various environmental factors like sea surface temperature (SST), salinity, and dissolved oxygen affect the blooms of Noctiluca scintillans, using advanced statistical methods.
- * The study found that SST and salinity significantly influence bloom occurrences, with SST having a 2-month lag and salinity a 1-month lag in their effects.
- * Additionally, the research identified a cyclical occurrence of blooms every 3 years and highlighted the need for a comprehensive approach considering multiple environmental factors to predict and manage harmful algal blooms (HABs).*
The Efficacy and Tolerability of Irbesartan/Amlodipine Combination Therapy in Patients With Essential Hypertension Whose Blood Pressure Were not Controlled by Irbesartan Monotherapy.
Clin Ther
June 2024
Article Synopsis
- The study evaluated the effectiveness and tolerability of combining irbesartan (IRB) and amlodipine (AML) in treating essential hypertension when IRB alone was insufficient.
- Two phase III clinical trials in Korea involved 428 patients and compared combinations of IRB/AML to placebo over 8 weeks, focusing on changes in mean sitting systolic blood pressure (MSSBP).
- Results showed significant reductions in MSSBP in the combination groups compared to monotherapy, with adverse events occurring in a small percentage of participants, indicating the combined therapy was both effective and tolerable.
Introduction: Evaluating the anticancer property of Padina boergesenii mediated bimetallic nanoparticles.
Methods: The present study focuses on synthesizing Se-ZnO bimetallic nanoparticles from an aqueous algal extract of brown algae .Synthesized Se-ZnO NPs were characterized by UV, FTIR, SEM-EDS and HRTEM for confirmation along with the anticancer activity by MTT assay.