Publications by authors named "B H De Rooij"
Skin wound healing is a physiological process orchestrated by epithelial and mesenchymal cells able to restore tissue continuity by re-organizing themselves and the ECM. This research study aimed to develop an optimized in vitro experimental model of full-thickness skin, to address molecular and morphological modifications occurring in the re-epithelization and wound healing process. Wound healing starting events were investigated within an experimental window of 8 days at the molecular level by gene expression and immunofluorescence of key epidermal and dermal biomarkers.
View Article and Find Full Text PDFBackground Setting: Punitive approaches to deter offending remain popular despite limited evidence of their effectiveness. This study investigated what effect presenting empirical criminological findings about the effectiveness of deterrence to a general public has on their punishment preferences. It builds on earlier research showing that such presentation reduces the public's inclination towards strict punishment.
View Article and Find Full Text PDFHealth related quality of life (HRQoL) is increasingly assessed in oncology research and routine care, which has led to the inclusion of HRQoL in prediction models. This review aims to describe the current state of oncological prediction models incorporating HRQoL. A systematic literature search for the inclusion of HRQoL in prediction models in oncology was conducted.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on understanding and predicting clinically relevant fatigue (CRF) in cancer patients two to three years after diagnosis, aiming to enhance supportive care for clinicians.
- Researchers examined data from 3160 patients with various cancer types, using both traditional logistic regression and advanced machine learning models to identify factors associated with CRF.
- While the logistic regression model showed good discrimination between patients with and without CRF, it also indicated potential underdiagnosis, raising concerns about the clinical applicability of the models used.
Objective: This study assessed the health-related quality of life (HRQo) of women surviving a borderline ovarian tumor (BOT) in comparison with early-stage ovarian cancer survivors treated surgically alone and with a matched cancer-free population.
Methods: Survivors of BOT and ovarian cancer were invited in two Dutch cross-sectional, population-based studies. Ovarian cancer survivors with tumor stage I who were treated surgically only were included.