Publications by authors named "B H C Stricker"
Effects and interaction of single nucleotide polymorphisms at the pharmacokinetic/pharmacodynamic site: insights from the Rotterdam study into metformin clinical response and dose titration.
Pharmacogenomics J
October 2024
Article Synopsis
- - Our study analyzed how genetic variations influence the effectiveness of metformin, a diabetes medication, in a group of 14,926 people over nearly three decades, focusing on 1,285 users of European descent.
- - We found that while most individual genetic markers didn't show strong links to drug response, one specific variant (rs622342) was associated with improved glycemic control in patients only taking metformin.
- - Although the combined effects of multiple genetic variants (measured by Polygenic Risk Score) had a weak correlation with changes in medication dosage, the limited impact suggests more research is needed, especially in different populations, to better understand genetic factors in diabetes treatment.
Research suggests that respiratory and cardiovascular drugs can ameliorate the rate of lung function decline. To investigate the impact of respiratory and cardiovascular pharmacotherapy on lung function trajectories in the general population. Repeated spirometry was performed in the Rotterdam Study, a population-based cohort of adults aged ≥45 years.
View Article and Find Full Text PDFLimited population-based data on the gender differences and association between arteriosclerotic calcification at different sites and atrial fibrillation (AF) exist. We aimed to investigate the (gender-specific) associations between arteriosclerotic calcification at different sites with the risk of AF in the general population. Arteriosclerotic calcification was quantified using computed tomography examinations between 2003 and 2006 in 2,259 participants free of AF from the population-based Rotterdam Study.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Mounting evidence underscores the dysregulation of miRNAs to be associated with cancer development and progression by acting as tumour suppressors and oncogenes. However, their potential as biomarkers for early diagnosis of different cancers remains incompletely unraveled.
View Article and Find Full Text PDFArticle Synopsis
- Several small genetic studies on atypical femur fractures (AFF) have been conducted, but results lacked replication; this study uses whole exome sequencing to analyze genetic factors in a larger sample of 139 European AFF cases and 196 controls.
- The analysis identified suggestive associations with genes like PLOD2, XRN2, and SORD, although not statistically significant; replication studies showed varying consistency across populations.
- Findings suggest that genetic factors influencing AFFs differ among individuals and highlight the need for larger studies to further understand the genetic basis of AFF.*