Lactating women and the perception of useful value for breastfeeding in a prison environment.

The aim is to unveil the useful value of breastfeeding for lactating women in a prison environment, based on Max Scheler's axiological perspective. This work was a qualitative, developed in a prison unit in Rio de Janeiro, where seven lactating women were interviewed. The phenomenological interview was used for data collection, while Laurence Bardin's content analysis was used for data analysis and treatment.

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models.

Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific for the human transferrin receptor 1 (TfR1), conjugated to an oligonucleotide via a cleavable valine-citrulline linker. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression.

Can chick meconium serve as a source of biomarkers linked to hatchling quality and the age of parent stock?

One possible approach to selecting chicks based on quality involves identifying biomarkers in biological samples. Concurrently, understanding the metabolic profile of chicks from different-aged breeders is essential for developing strategies to mitigate the age-related effects on hatchability. This study investigated whether chick quality and breeder age influence the metabolic profile of layer chick meconium.

Coordinated regulation of eosinophil production and migration by glucocorticoids, prostaglandins, and cysteinyl-leukotrienes.

Introduction: The spectrum of eosinophil functions has expanded from fighting helminths to multiple novel roles in malignancy, infection, cancer, and metabolism. In asthma, glucocorticoids, prostaglandins (PG), and cysteinyl-leukotrienes (LT) regulate eosinophil biology through separate signaling pathways. Here we've evaluated the complex interplay between Dexa, PGE2, and CysLTs in eosinopoiesis and eosinophil biology in an allergic asthma model.

A multimodal neural signature of face processing in autism within the fusiform gyrus.

Atypical face processing is commonly reported in autism. Its neural correlates have been explored extensively across single neuroimaging modalities within key regions of the face processing network, such as the fusiform gyrus (FFG). Nonetheless, it is poorly understood how variation in brain anatomy and function jointly impacts face processing and social functioning.