A rare complication of a thoracic wound: the pneumopericardium?

Pneumopericardium (PPC) is defined by the presence of gas in the pericardial cavity, often leading to cardiac tamponade and a high mortality rate. This report describes a case involving a 33-year-old man found deceased a few meters from a knife, his clothes intact, with no resuscitation attempt made. A knotted scarf was tightly fastened around his neck, without ligature mark.

EPR17341 and A7H6R pan-TRK Immunohistochemistry Result in Highly Different Staining Patterns in a Series of Salivary Gland Tumors.

Patients with NTRK-rearranged tumors can be now treated using anti-TRK-targeted therapies making NTRK testing important for treatment choices in patients with advanced cancers. Pan-TRK immunohistochemistry (IHC) could be a valuable premolecular screening strategy in this field. The choice of 1 IHC method or another requires to investigate for intermethod comparison.

Testing for fusions in patients with advanced // wild-type melanomas permits to identify patients who could benefit of anti-MEK targeted therapy.

Beyond targeted therapy for patients with -mutated melanomas and immunotherapy in patients lacking mutations, anti-MEK therapy has been proposed in patients with advanced melanomas harbouring fusions. fusions diagnosis in patients with advanced melanomas is the subject of the present study. Using fluorescent in situ hybridisation (FISH), we searched for fusions in 74 samples of 66 patients with advanced // wild-type melanomas.