Publications by authors named "B Guerin"
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Background: Clinicopathological studies of Alzheimer's disease (AD) have demonstrated that synaptic or neuronal loss and clinical cognitive decline do not reliably correlate with fibrillar amyloid burden. We created a transgenic mouse model overexpressing Dutch (E693Q) mutant human amyloid precursor protein (APP) driven by the pan-neuronal Thy1 promoter. Accumulation of APP carboxyl-terminal fragments was observed in the brains of these mice, which develop an impaired learning phenotype directly proportional to brain oAβ levels.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease characterized by motor neuron loss in the motor cortex, brain stem, and spinal cord. Mutations in the superoxide dismutase 1 (SOD1) gene, resulting in misfolding of its protein product, are a common cause of ALS. Currently, there is no approved ALS diagnostic tool.
View Article and Find Full Text PDFArticle Synopsis
- Magnetic fields that switch at high frequencies (kHz) can cause peripheral nerve stimulation (PNS) in the body, and this has primarily been studied below 10 kHz.
- Previous studies above ~25 kHz showed inconsistent results with high variability, but new research involving 8 volunteers measured PNS at frequencies from 200 Hz to 88.1 kHz.
- Results indicated that instead of continuously decreasing, the PNS thresholds hit a minimum around 25 kHz and then increased by 39% from that point to 88.1 kHz, highlighting the need for more research on the biological mechanisms behind magnetostimulation at these higher frequencies.
Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. This was a multisite prospective observational study in which mCRPC patients underwent both F-FDG and Ga-prostate-specific membrane antigen (PSMA)-617 PET/CT scans.
View Article and Find Full Text PDFBackground: Transcranial focused ultrasound (tFUS) neuromodulation has shown promise in animals but is challenging to translate to humans because of the thicker skull that heavily scatters ultrasound waves.
Objective: We develop and disseminate a model-based navigation (MBN) tool for acoustic dose delivery in the presence of skull aberrations that is easy to use by non-specialists.
Methods: We pre-compute acoustic beams for thousands of virtual transducer locations on the scalp of the subject under study.