Sentinel node biopsy in breast cancer.

Regional lymph node involvement is the most important prognostic indicator in most solid tumors. Lymph nodes first to receive the lymphatic flow from the peritumoral region are called sentinel nodes. Extirpation methodology of these nodes is rather short (around 10 years) and is related to the following names: Cabanas, Morton, Uren, Berman, Glass, Alex, Cragg.

[Modern dilemmas in the treatment of breast carcinoma].

By means of a detailed analysis of literature data and our own results when available, the paper presents different therapeutic options in the treatment of breast cancer patients that are applied in our country today and the that might be applied in relation to modern knowledge and discoveries in experimental oncology, early detection and diagnostics of breast cancer. It is stressed that the use of this knowledge may result in slightly better rate of survival but the main emphasis is on the quality of life of treated patients and more rational delivery of available therapeutic options.

[Goals and scientific achievements of the Institute of Oncology].

The Institute of oncology represents an oncological center which renders the measures of prevention, early detection and diagnostic of tumours and multidisciplinary strategy for antitumour treatment, including rehabilitation of patients suffering from tumours. To fulfil the above mentioned aims the Institute is organized in ten completely operative units and several functional centres and committees. The paper presents only few aspects of diagnostic and treatment of tumour, and the implementation of the programmes and targets of individual organizational units within the Institute.

Prognostic variables in patients with gastrointestinal carcinoid tumours.

Prognostic variables in patients with gastrointestinal carcinoid tumour were studied with a view to identifying those most likely to benefit from aggressive therapy. A total of 188 patients were studied; the median follow-up of those surviving was 72 months. On univariate analysis variables of prognostic significance were sex (P < 0.