The Effect of Sertraline on Hemodynamic Parameters and Nitric Oxide Production in Isolated Rat Hearts Subjected to Ischemia and Reperfusion.

Purpose: The aim of the study was to investigate the effect of sertraline on the rat heart during ischemia and reperfusion and to determine its effect on NO production.

Materials And Methods: The study was performed on isolated rat hearts. Hearts from three groups were perfused with sertraline at three different concentrations and subjected to global ischemia and reperfusion.

The Negative Impact of Selective Activation of Retinoic Acid Receptors on Bone Metabolism and Bone Mechanical Properties in Rats.

Background: Drug-induced osteoporosis is a significant health problem, as many drugs have deleterious effects on bone metabolism. Data from several studies concerning the influence of retinol on bone homeostasis are inconsistent.

Objectives: The purpose of this study was to investigate the influence of tazarotene, a selective agonist of the retinoic acid receptor (RAR), on bone metabolism and bone mechanical properties in rats.

Behavior of silica particles introduced into an isolated rat heart as potential drug carriers.

Silica powders consisting of small spherical particles (50-200 nm) have been obtained by the sol-gel method. A suspension of such particles in the Krebs-Hanseleit solution has been introduced into the coronary circulation of a beating perfused rat heart. The influence of the suspension on the heart muscle and the coronary vessels in the rat body has been histopathologically examined.

Effect of aging process on liver function in extracorporeal rat liver perfusion.

Background/aims: Liver function appears to be well maintained in old age. However, the current state of knowledge about liver aging processes is incomplete. In this study, using extracorporeal liver perfusion model, we evaluated the differences between liver function in young and old rats.

[Phenotypes of oxidation and acetylation in Alzheimer's disease--preliminary report].

Aim: The relationship between genetically determined polymorphic oxidation and acetylation and susceptibility to some disease has aroused much interest. The aim of our study was to evaluate whether patients with Alzheimer's disease differ from healthy persons in their ability to oxidize sparteine and acetylate sulphadimidine as model substance.

Method: Oxidation and acetylation phenotype were estimated in 20 patients with Alzheimer's disease.