FoxK mediates TGF-beta signalling during midgut differentiation in flies.

Inductive signals across germ layers are important for the development of the endoderm in vertebrates and invertebrates (Tam, P.P., M.

[Spanish scientific output on thirty pathologies of genetic origin].

Introduction: The Spanish scientific output during the years 2000-2005 on 30 pathologies of genetic origin included in the OCDE survey on molecular genetic testing has been studied.

Results: A total of 105 articles were in MedLine journals on 20 of the pathologies considered. This represents 0.

EVG, the remnants of a primordial bilaterian's synteny of functionally unrelated genes.

Extant genomes are the result of repeated duplications and subsequent divergence of primordial genes that assembled the genomes of the first living beings. Increased information on genome maps of different species is revealing conserved syntenies among different vertebrate taxa, which allow to trace back the history of current chromosomes. However, inferring neighboring relationships between genes of more primitive genomes has proven to be very difficult.

DmFoxF, a novel Drosophila fork head factor expressed in visceral mesoderm.

DmFoxF is a novel Drosophila fork head domain factor, which is expressed in the visceral mesoderm of the embryo. Our data suggest that DmFoxF is the fly orthologue of the vertebrates FOXF1 and FOXF2 transcription factors. DmFoxF shares homology with FOXF1 and FOXF2 in its fork head domain, and it is able to specifically bind DNA sequences recognized by these vertebrate fork head factors.

Fhx (Foxj2) expression is activated during spermatogenesis and very early in embryonic development.

FHX (FOXJ2) is a recently characterized human fork head transcriptional activator that binds DNA with a dual sequence specificity. We have cloned the cDNA for the mouse orthologue Foxj2 and characterized its expression in the gonads and along the early pre-implantation development of the mouse. In the testis, Foxj2 is expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia.