Publications by authors named "B Graf"
Article Synopsis
- Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
- A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
- The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
Adeno-associated viruses (AAV) are widely used viral vectors for in vivo gene therapy. The purification of AAV, particularly the separation of genome-containing from empty AAV capsids, is usually time-consuming and requires expensive equipment. In this study, we present a novel laboratory scale anion exchange flow-through polishing method designed to separate full and empty AAV.
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- The significance of prehospital cervical spine immobilization in trauma patients is debated, especially due to potential negative effects like increased intracranial pressure, necessitating further research on the long-term use of rigid orthoses.
- A study was conducted comparing cervical spine mobility when using a vacuum mattress with and without a rigid orthosis during simulated emergency transport in an ambulance.
- Results showed statistically significant differences in biomechanical parameters, indicating that the use of a rigid orthosis may impact cervical spine movement during transport, but further investigation is needed to draw firm conclusions.
Article Synopsis
- A significant number of COVID-19 patients with severe acute respiratory distress syndrome developed secondary sclerosing cholangitis (SSC) as a liver complication during the pandemic.
- 17 patients were diagnosed and treated for COVID-19 SSC at a medical center between February 2020 and October 2022, with data analyzed to identify risk factors and treatment methods.
- The study found that 2.6% of severe COVID-19 patients developed SSC, with high mortality rates; however, endoscopic treatments showed promise in managing biliary issues and could serve as a bridge to liver transplantation.