Publications by authors named "B Grace"
The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression and phenotype. To understand tumor biology and accurately test new therapeutic strategies, representative models should contain both tumor cells and normal cells of the TME. Here, we describe and characterize co-culture tumor-derived organoids and cancer-associated fibroblasts (CAFs), a major component of the TME, in matrix-embedded assembloid models of esophageal adenocarcinoma (EAC).
View Article and Find Full Text PDFand neighborhood socioeconomic vulnerability in the state of Maryland from 2019 to 2022.
Infect Control Hosp Epidemiol
July 2024
Background: is an emerging fungal pathogen increasingly recognized as a cause of healthcare-associated infections including outbreaks.
Methods: We performed a mixed-methods study to characterize the emergence of in the state of Maryland from 2019 to 2022, with a focus on socioeconomic vulnerability and infection prevention opportunities. We describe all case-patients of among Maryland residents from June 2019 to December 2021 detected by Maryland Department of Health.
Article Synopsis
- Oesophagogastric cancer surgery outcomes are generally poor, leading researchers to investigate the effectiveness of cardiopulmonary exercise testing (CPET) in predicting postoperative results, especially after neoadjuvant treatments.
- A study included 611 patients from seven UK centers, analyzing the relationship between peak oxygen uptake (VO peak) and one-year survival, finding no significant correlation, but noting that anaerobic threshold measures related to ideal body weight were predictive of three-year survival.
- Key factors influencing survival included tumor characteristics and major complications, with specific CPET metrics showing some predictive value but not universally across the entire cohort.