Publications by authors named "B Gottstein"
Article Synopsis
- Alveolar echinococcosis (AE) is a rare, severe disease impacting over 18,000 people globally each year.
- Recent advancements in sequencing the mitochondrial genome of Echinococcus multilocularis have enabled researchers to explore the genetic diversity and evolution of the parasite.
- Analysis of 113 samples from various regions revealed four main haplogroups (HG1, HG2, HG3, and a potential HG4), with HG3 further divided into three micro-haplogroups, showing distinct geographical clusters and including new patient samples from areas outside historical endemic zones in France.
Article Synopsis
- Echinococcus multilocularis is a parasitic cestode causing a deadly disease called alveolar echinococcosis, primarily spread by red foxes in Europe.
- The study investigated genetic diversity among E. multilocularis isolates from 19 European countries, analyzing 4,968 base pairs from five mitochondrial genes and identifying 43 different haplotypes.
- Findings indicated that most of the isolates shared four predominant haplotypes concentrated in mainland Europe, while Svalbard's isolates were genetically distinct, highlighting the need for more research in underrepresented eastern European regions to understand genetic variability.
Introduction: Recurrence after curative resection of hepatic alveolar echinococcosis remains a clinical challenge. The current study tested if assessment of anti-recEm18 allows for postsurgical patient surveillance.
Methods: A retrospective study with patients undergoing liver resection for alveolar echinococcosis (n = 88) at the University Hospital Bern from 2002 to 2020 and at the University Hospital and Medical Center Ulm from 2011 to 2017 was performed.
Objectives: The diagnosis of larval cestodiases in humans primarily depends on using imaging techniques in combination with serological tests. However, in case of atypical imaging results, negative serology results due to immunosuppression, or infection with rare taeniid species, traditional diagnostic tools may not provide a definitive species-level diagnosis. We aimed to validate a rapid, reliable, and cost-effective single-step real-time PCR method that can identify and differentiate larval cestodiases from biopsy material.
View Article and Find Full Text PDFMonoclonal antibody-based localization of major diagnostic antigens in metacestode tissue, excretory/secretory products, and extracellular vesicles of species.
Front Cell Infect Microbiol
April 2023
Alveolar (AE) and cystic echinococcosis (CE) are severe parasitic zoonoses caused by the larval stages of and , respectively. A panel of 7 monoclonal antibodies (mAbs) was selected against major diagnostic epitopes of both species. The binding capacity of the mAbs to spp.
View Article and Find Full Text PDF