Publications by authors named "B Gornicka"
A rodent eyeball is a powerful tool for researching the pathomechanisms of many ophthalmic diseases, such as glaucoma, hypertensive retinopathy, and many more. Preclinical experiments enable researchers to examine the efficacy of novel drugs, develop new methods of treatment, or seek new pathomechanisms involved in the disease's onset or progression. A histological examination provides a lot of information necessary to assess the effects of the conducted experiments and can reveal degeneration, tissue remodeling, infiltration, and many other pathologies.
View Article and Find Full Text PDFBackground Quantifying the fibrotic and calcific composition of the aortic valve at CT angiography (CTA) can be useful for assessing disease severity and outcomes of patients with aortic stenosis (AS); however, it has not yet been validated against quantitative histologic findings. Purpose To compare quantification of aortic valve fibrotic and calcific tissue composition at CTA versus histologic examination. Materials and Methods This prospective study included patients who underwent CTA before either surgical aortic valve replacement for AS or orthotopic heart transplant (controls) at two centers between January 2022 and April 2023.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of end-ischemic dual hypothermic oxygenated machine perfusion (dHOPE) compared to static cold storage (SCS) for preserving livers from brain-dead donors.
- A total of 104 liver transplant recipients were analyzed, focusing on biliary complications and graft survival over two years, with dHOPE showing promising results primarily in high-risk grafts.
- The findings indicate that while dHOPE did not significantly improve outcomes in low-risk cases, it led to 100% graft survival in high-risk patients compared to 73.1% with SCS.
Pathologic Analysis of Twenty-one Appendices From Children With Multisystem Inflammatory Syndrome Compared to Specimens of Acute Appendicitis: A Cross-sectional Study.
Pediatr Infect Dis J
June 2024
Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare, severe complication of coronavirus disease 2019, commonly involving the gastrointestinal tract. Some children with MIS-C undergo appendectomy before the final diagnosis. There are several hypotheses explaining the pathomechanism of MIS-C, including the central role of the viral antigen persistence in the gut, associated with lymphocyte exhaustion.
View Article and Find Full Text PDFIntroduction: A tumor microenvironment plays an important role in bladder cancer development and in treatment response.
Purpose: The aim of the study was to assess how the components of the microenvironment affect tumor recurrence and to find the potential biomarkers for immunotherapy in NMIBC.
Methods: The study group consisted of 55 patients with primary NMIBC.